Remedy for regulating the degree of acidity of the gastric juice



y 1937. F. KOROSY 2,079,512

REMEDY FOR REGULATING THE DEGREE OF ACIDITY OF THE GASTRIC JUICE Filed March 51, 1934 1752/950 10 2o 50 4o 50 6 0 ;b 8o 90 .100 I00 90 50 f0 60 50 4o 50 2o 10 O Ma/9g P0 1950 Patented May 4, 1937 UNITED" STATES PATENT OFFICE nmnr ron amnu'rmo THE nacnaa or acmrrr or run GASTRIC JUICE Franz Kill-day, Budapest, Hungary Application March 31, 1934, Serial No. 718,464

In Hungary April 29, 1933 4 Claims. (01. 167-55) The stomach only functions correctly when the degree of acidity of the contents of the stomach exceeds the minimum value (pH=4) necessary for the action of the pepsin, but does not attain 5 the concentration (pH=l.5) at which the stomach is attacked. For regulating the acid content of the stomach, in the case of superacidity, hitherto either the secretion of acid itself was'paralyzedfliy doses of strong poisons (for example, atropinl'or the acid which is already secreted was neutralized, for example by comparatively strong alkaline substances (sodium bicarbonate, magnesia, magnesium carbonate or calcium carbonate), or was partly combined by 15 means of more weakly acting compounds containing alumina andsilica.

. The strongly alkalineremedies, it is true, produce in most cases a momentary alleviation, but the stomach, having. become alkaline, cannot g digest without acid, and reacts with an increased secretion of acid, so that continued use of such remedies results in an increase in the superacidity of the stomach.

The diagram in Figure 1 shows the variation of V the pH in 50 cubic centimetres of a 0.1 normal hydrochloric acid solution caused by the addition of sodium bicarbonate or magnesia. The ordinates represent the pH values. pH=7 corresponds to the neutral solution, so that the alkaline region lies above the line Z, while the acid region lies below the said line. The lines X and Y represent the permissible lowest limit (1.5) and highest limit (4.0), respectively, of the pH the gastric juice. The pH of the contents of the stomach must therefore lie in the region between the lines X and Y. The lines A and B show the variations of the pH value caused by an addition of sodium bicarbonate and magnesia,

respectively. The curves show that, with 0.08

reached the line x, whereas a minimum increase of the magnesia, that is only to 0.1-0.12 gram, results in the upper limit Y of the normal acidity being exceeded, the solution becoming thereby neutral and even alkaline. Conditions with sodium bicarbonate are somewhat favourable,

because the acidity decreases at the commencel ment somewhat more slowly thanivith magnesia, and the region of normal acidity is only attained with 0.3 gram. In this case also, however, even quite a small increase of the addition effects a sudden increase in the' pH value, so that even 0.43 gram is suflicient to cause the region of normal acidity to be exceeded. Thus, even quite small excess amounts of such alkalizing remedies gram of magnesia, the pH value has not yet lower the acidity below the permissible lowest, limit, because of course the excess amounts tend to cause the pH value to approach the actual pH value of the magnesia or sodium bicarbonate solution, which value is above 7.5 for sodium bicarbonate and even above for magnesia. It is therefore clear that, even with accurately measured quantities of such alkalizing remedies, the degree of acidity of the contents of the stomach can only be adjusted to the normal value if the quantity of the contents of the stomach, and

their degree of acidity are previously accurately ascertained at the moment of taking the remedy. Even this is not sufficient, because for example in nervous ailments of the stomach, superacidity alternates with inacidity within comparatively short periods, while the symptoms in both cases bear a considerable resemblance to each other, for which reason the sick person always takes the same medicine for them, even if the acid condition of the stomach has altered in the meantime. Such a wrong treatment may of course have serious consequences. This latter disadvantage is also not eliminated by the weakly alkaline remedies containing aluminium silicate which have been proposed in place of the strongly alkaline remedies, but which also possess the disadvantage that, although they are less sensitive in regard to the amounts taken they require exceptionally large doses, attaining 10 grams, for providing the normal acidity. Of course, all these remedies, being alkaline (pH about 8) may also lower the the degree of acidity of the gastric Juice below the permissible limit.

In contradistinction thereto, this invention relates to the manufacture of a remedy which in all circumstances adjusts the degree of acidity of the stomach contents, both in the case of a superacid and an in-acid stomach, independently of the initial value of the said degree of acidity and of any excess amount of the remedy.

The essential feature of the invention resides in the fact that a buffer mixture is made from compounds having a salt character with compounds of acid reaction, the pH value of the said buffer mixture, both in concentrated solution, and also in the-maximum dilution occurring in the stomach, lying within the region of the normal acidity of the gastric Juice, that is to say, within the values of 1.5 and 4. Since the pH value of the buffer mixture is to a relatively high degree independent both of the degree of dilution and the quantity of the acid entering into the solution, that is to say, it remains within the limits of the normal acidity of the stomach, a butter mixture corresponding to the foregoing conditions will adjust the'degree'ot acidity oi the stomach contents to the normal acidity.

' be employed as acid component for the butler mixture according to the invention, while the Anyacld or acid-mixture, which is physiolog-i 'ically non poisonou's and which has its Ml? tion constant lying between 10-" and-10 may other component of the bufler mixture maybe either a salt of this acid or another salt. Acid saltsmay be employed instead of, acids or salts.

- tides may be employed as salt component of the buiier mixture. Since the molecule of these compounds contains both acid and basic groups, they behave as salts from the point of view or the pH. The salts of these compounds formed with acid, however, act already as strongly acid salts and may act in the bufier mixture as acids.

Buffer mixtures may therefore be formed advantageously as follows: orthophosphoric acid and primary phosphates; pyrophosphoric acid or primary pyrophosphates and secondary pyrophosphates, dithionic acid and primary dithionates; bisulphates and sulphates, dithiosulphates and thiosulphates; aminophosphoric acid and primary'aminophosphates; citric acid and primary citrates; lactic acid, malic acid, glycolic acid, glyceric acid, iumaric acid, malonic acid, tartaric acid, ortho-acetoxy-benzoic acid, mandelic acid, adenosine-phosphoric' acid, inosine acid, creatinine-phosphoric acid and the salts or primary salts of these acids; the above-mentioned amino acids and their. acid salts, for example, glycocoll and its hydrochloride or sulphates, furthermore, phenylglycocoll, alanine, leucine, aspartic acid, alanylglycine, glycylglycine; leucylglycinel, and their acid salts and so forth. It is remarked that it is not necessary in each case to mix the phosphoric acid or acid salts, for example, bisulphates, glycine hydrochlorides or betainehydrochlorides may be employed which liberate phosphoric acid after the solution of the mixture. In selecting the components of the butter mixtures, the specific action of the anions oi the components of the mixture may also be taken into consideration, it the specific action of such anions is to be efiective in addition to the bufler action of the mixture.

The mixing proportion of the components of the bufier mixture must be so determined that thepH value of the solution of the mixture both in the concentrated state and also in the maximum dilution attainable in the stomach falls within the region of the normal acidity of the stomach. Thus, for example, in the case of the remedy made from a solid mixture of sodium bisulphate (NaHSOr) and monosodium-phosphate (NaH2PO4.H2O) the mixing proportion may I be obtained from the diagram in Figure 2. The

ordinates give the pH value of the solutions of the respective mixtures. The curve C for the concentrated solution, and the curve D for the 0.5% solution, show the connection between the ma a mixing proportion and the pH values. 'ihe lines I and Y bound the region of permissible acidity oi the stomach. 4

- 'Ihese curves show-that, ior regulating the acid contents of the stomach, anymixing proportion is suitable,- the pH of which is within the area bounded by the lines x, Y, C, D. The 0.5% solution corresponds to the maximum dilution oc-I curring in the stomach. -The pH'should not ex ceed 4.0, that is .to say, the butter mixture may contain not less than 3%foi sodium bisulphate;

in accordance with the point of intersection of the hues D and Y. Since, however, it is necessary to take into consideration the fact that the remedy taken in the solid state into the stomach ,forms initially a concentrated solution and the .the point of intersection oi the lines C and X.

The more bisulphatethe buffer mixture contains, that is to say, the more its acid character is predominant, the greater are the quantities required for neutralizing a given superacidity, whereas an inacid stomach is acidified all the more readily. Within the two limits, therefore, the mixing proportions may be selected ireely according as to whether the desired effect is to be obtained with greater or smaller quantities, and as to whether the desired magnitude of the final value oi the pH to be attained by the remedy lies within the limits 1.5 and 4.0. 3

Figure 3 shows for example the efiect obtained .by the'addition of a mixture containing 14% of bisulphate or 17% bisulphate to 50 cubic centimetres oi. a hydrochloric acid solution with 1.1 pH, corresponding to a strongly acid stomach content. The lines X and Y are the limits oi the normal acidity of the stomach. The curves E and F correspond to the buffer mixtures with 14% sodium sulphate and 17% sodium bisulphate respectively. Ne and Ni denote the actual pH values of the 20% solutions of a bufler mixture containing 14% and 17% of sodium bisulphate, respectively. The diagrams show that on the addition oi. the buffer solution, the pH value at first increases uniformly, that is to say, the degree of acidity diminishes correspondingly. Above the line X, that is to say, as soon as the curves have reached the region 01' normal acid content, the degree of acidity no longer diminishes in proportion-to the added quantity of the bufier solution, but the pH curve gradually approaches the value Ne or Nf of the pH of the bufler solution itself, that is to say, it remains within the region of normal degree of acidity.

The mixture according to the invention may be produced in the solid state or as a solution. In the latter case, it is not the pH value of the concentrated solution but that of the solution of these components to be employed which must fall within the limit oi. 1.5, because this latter concentration constitutes the maximum concentration occurring in the stomach.

Inert substances for improving the taste may be added to the remedy and furthermore foods or other remedies, for example pepsin may be added, since the normal acidity of the stomach as ensured by the bufler mixture assists the action of other remedies taken at the same time.

What I claim-is:

- 1. A remedy for restoring the normal acidity of the stomach consisting of a mixture of compounds of which one at least is selected from a 75 group which possesses a dissociation constant relative to free hydrogen ions from 10 to 10-, while the other one has a smaller dissociation constant and is present in such a proportion that 5 the mixture will yield an aqueous solution'which when concentrated has'a pH value above 1.5 and when diluted as far as about 0.5% has a pH value below 4.

2. A remedy for restoring the normal acidity oi the stomach comprising a buffer mixture having an acid component and a salt component, said acid component being selected from a group having a dissociation constant relative to free hydrogen ions from 10-- to 10- the other com- 5 ponent having a smaller dissociation constant and beingpresent in such proportion that the mixture will yield an aqueous solution which when concentrated has a DH value above about 1.5 and when diluted as far as about 0.5% has a 20 pH value below about 4.

3. A remedy for restoring the normal acidity of the stomach consisting of a dry mixture of 3 to 17% sodium bisuiphate and 97 to 83% monosodium-phosphate adapted to form a bufler solution.

4. A remedy for restoring the normal acidity of the stomach, comprising a solid mixture of acid and salt components, of which at least one is selected from a group possessing a dissociation constant relative to free hydrogen ions higher than- 10- and at least one other is selected from a group of compounds possessing a dissociation constant relative to free hydrogen ions lower than 10- and being mixed in a proportion so that the mixture will yield an aqueous solution which when concentrated has a pH value about 1.5 and when diluted as faras about 0.5% has DH value below about 4.

FRANZ xonosy. 

